MICU Resident Reading List
Acid Base
- Forsythe SM1, Schmidt GA. Sodium bicarbonate for the treatment of lactic acidosis. Chest. 2000 Jan;117(1):260-7.
Acute Respiratory distress Syndrome (ARDS)
- Acute Respiratory Distress Syndrome Network. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. N Engl J Med. 2000;342:1301-8.
- Acute Respiratory Distress Syndrome Network. Comparison of two fluid-management strategies in acute lung injury. N Engl J Med. 2006;354:2564-75.
- Briel M, Meade M, et al. Higher vs lower PEEP in patients with acute lung injury and acute respiratory distress syndrome – systematic review and meta-analysis. JAMA. 2010;303(9):865-873.
- Herridge MS, Cheung AM, et al. One-year outcomes in survivors of the acute respiratory distress syndrome. N Engl J Med. 2003;348:683-93.
- Papazian L, Forel JM, et al. Neuromuscular blockers in early acute respiratory distress syndrome. N Engl J Med. 2010. 363(12): 1107-1116.
- Piantadosi CA and Schwartz DA. The Acute Respiratory Distress Syndrome. Ann Intern Med.2004;141:460-470. [Review of the physiology of ARDS]
Antibiotic Therapy
- Baddour LM, Wilson WR, et al. Infective Endocarditis in Adults: Diagnosis, Antimicrobial Therapy, and Management of Complications: A Scientific Statement for Healthcare Professionals From the American Heart Association. Circulation. 2015 Oct 13;132(15):1435-86. doi: 10.1161/CIR.0000000000000296. Epub 2015 Sep 15.
- Chastre J1, Wolff M. Comparison of 8 vs 15 days of antibiotic therapy for ventilator-associated pneumonia in adults: a randomized trial. JAMA. 2003 Nov 19;290(19):2588-98.
- Ibrahim EH, Sherman G, et al. The influence of inadequate antimicrobial treatment of bloodstream infections on patient outcomes in the ICU setting. Chest. 2000 Jul;118(1):146-55.
- Kalil AC, Metersky ML,et al. Management of Adults With Hospital-acquired and Ventilator-associated Pneumonia: 2016 Clinical Practice Guidelines by the Infectious Diseases Society of America and the American Thoracic Society. Clin Infect Dis. 2016 Sep 1;63(5):e61-e111. doi: 10.1093/cid/ciw353. Epub 2016 Jul 14.
- Kollef MH, Sherman G, et al. Inadequate antimicrobial treatment of infections: a risk factor for hospital mortality among critically ill patients. Chest. 1999 Feb;115(2):462-74.
- Mandell LA, Wunderink RG, et al. Infectious Diseases Society of America/American Thoracic Society consensus guidelines on the management of community-acquired pneumonia in adults. Clin Infect Dis. 2007 Mar 1;44 Suppl 2:S27-72.
- Marik PE, Careau P. The role of anaerobes in patients with ventilator-associated pneumonia and aspiration pneumonia: a prospective study. Chest. 1999 Jan;115(1):178-83.
- Tunkel AR, Hartman BJ,et al. Practice guidelines for the management of bacterial meningitis. Clin Infect Dis. 2004 Nov 1;39(9):1267-84. Epub 2004 Oct 6.
Blood Products
- Hébert PC, Wells G, et al. A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care. Transfusion Requirements in Critical Care Investigators, Canadian Critical Care Trials Group. N Engl J Med. 1999 Feb 11;340(6):409-17.
- Villanueva C, Colomo A, et al. Transfusion strategies for acute upper gastrointestinal bleeding. N Engl J Med. 2013 Jan 3;368(1):11-21. doi: 10.1056/NEJMoa1211801.
Critical Care Ultrasound
- Boniface KS1, Calabrese KY. Intensive care ultrasound: IV. Abdominal ultrasound in critical care. Ann Am Thorac Soc. 2013 Dec;10(6):713-24. doi: 10.1513/AnnalsATS.201309-324OT.
- Cardenas-Garcia J, Mayo PH. Bedside ultrasonography for the intensivist. Crit Care Clin. 2015 Jan;31(1):43-66. doi: 10.1016/j.ccc.2014.08.003. Epub 2014 Oct 3.
- Lichtenstein D. Lung ultrasound in the critically ill. Curr Opin Crit Care. 2014 Jun;20(3):315-22. doi: 10.1097/MCC.0000000000000096.
- Lichtenstein DA. Ultrasound in the management of thoracic disease. Crit Care Med. 2007 May;35(5 Suppl):S250-61.
Endocrine issues in the ICU
- Marik PE, Pastores SM, et al. Recommendations for the diagnosis and management of corticosteroid insufficiency in critically ill adult patients: Consensus statements from an international task force by the American College of Critical Care Medicine. Crit Care Med. 2008; 36:1937–1949.
- NICE-SUGAR Study Investigators. Intensive versus conventional glucose control in critically ill patients. N Engl J Med. 2009;360:1283-97.
- NICE-SUGAR Study Investigators. Hypoglycemia and risk of death in critically ill patients. N Engl J Med. 2012 Sep 20;367(12):1108-18.
- van den Berghe G, Wouters P. et al. Intensive insulin therapy in critically ill patients. N Engl J Med. 2001 Nov 8;345(19):1359-67.
Fluid Management
- Boyd JH. Fluid resuscitation in septic shock: a positive fluid balance and elevated central venous pressure are associated with increased mortality. Crit Care Med. 2011 Feb;39(2):259-65. doi: 10.1097/CCM.0b013e3181feeb15.
- Durairaj L, Schmidt GA. Fluid therapy in resuscitated sepsis: less is more. Chest. 2008 Jan;133(1):252-63. doi: 10.1378/chest.07-1496.
- Finfer S. A comparison of albumin and saline for fluid resuscitation in the intensive care unit. N Engl J Med. 2004 May 27;350(22):2247-56.
- Marik PE, et al. Hemodynamic parameters to guide fluid therapy. Ann Intensive Care. 2011 Mar 21;1(1):1. doi: 10.1186/2110-5820-1-1.
- Marik PE, Does central venous pressure predict fluid responsiveness? A systematic review of the literature and the tale of seven mares. Chest. 2008 Jul;134(1):172-8. doi: 10.1378/chest.07-2331.
- Murphy CV, et al. The importance of fluid management in acute lung injury secondary to septic shock. Chest. 2009 Jul;136(1):102-9. doi: 10.1378/chest.08-2706. Epub 2009 Mar 24.
- Myburgh JA. Hydroxyethyl starch or saline for fluid resuscitation in intensive care. N Engl J Med. 2012 Nov 15;367(20):1901-11. doi: 10.1056/NEJMoa1209759. Epub 2012 Oct 17.
- National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome (ARDS) Clinical Trials Network. Comparison of two fluid-management strategies in acute lung injury. N Engl J Med. 2006 Jun 15;354(24):2564-75. Epub 2006 May 21.
- National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome (ARDS) Clinical Trials Network. Pulmonary-artery versus central venous catheter to guide treatment of acute lung injury. N Engl J Med. 2006 May 25;354(21):2213-24. Epub 2006 May 21.
- Perel P, et al. Colloids versus crystalloids for fluid resuscitation in critically ill patients. Cochrane Database Syst Rev. 2013 Feb 28;(2):CD000567. doi: 10.1002/14651858.CD000567.pub6.
GI Bleeding in the ICU
- Cook DJ, Fuller HD, et al. Risk factors for gastrointestinal bleeding in critically ill patients. N Engl J Med. 1994; 330:377-381.
HIV in the ICU
- Huang L, Quartin A, et al. Intensive care of patients with HIV infection. N Engl J Med. 2006;355:173-81.
Mechanical ventilation
- Boles JM et al. Weaning from mechanical ventilation. Eur Respir J. 2007; May 29 (5): 1033-56.
- Brochard L. Comparison of three methods of gradual withdrawal from ventilatory support during weaning from mechanical ventilation. Am J Respir Crit Care Med. 1994 Oct;150(4):896-903.
- Ely EW, Baker AM, et al. Effect of the duration of mechanical ventilation of identifying patients capable of breathing spontaneously. N Engl J Med. 1996;335:1864-9.
- Esteban A, et al.Effect of spontaneous breathing trial duration on outcome of attempts to discontinue mechanical ventilation. Spanish Lung Failure Collaborative Group. Am J Respir Crit Care Med. 1999 Feb;159(2):512-8.
- Esteban A, et al. A comparison of four methods of weaning patients from mechanical ventilation. Spanish Lung Failure Collaborative Group. N Engl J Med. 1995 Feb 9;332(6):345-50.
- Girard TD, Kress JP, et al. Efficacy and safety of a paired sedation and ventilator weaning protocol for mechanically ventilated patients in intensive care (Awakening and Breathing Controlled trial): a randomized controlled trial. Lancet. 2008; 371: 126–34.
- MacIntyre M. Discontinuing mechanical ventilatory support. Chest. 2007; 132: 1049-1056.
- Tobin MJ. Advances in mechanical ventilation. N Engl J Med. 2001; 344:1986-96. [Intended for review of some basic concepts of the ventilator, including patient-ventilator interactions].
Pharmacology
- Jakob SM, Dexmedetomidine vs midazolam or propofol for sedation during prolonged mechanical ventilation: two randomized controlled trials. JAMA. 2012 Mar 21;307(11):1151-60. doi: 10.1001/jama.2012.304.
- Kress JP, et al., Daily interruption of sedative infusions in critically ill patients undergoing mechanical ventilation. N Engl J Med. 2000 May 18;342(20):1471-7.
- Pandharipande PP, et al., Effect of sedation with dexmedetomidine vs lorazepam on acute brain dysfunction in mechanically ventilated patients: the MENDS randomized controlled trial. JAMA. 2007 Dec 12;298(22):2644-53.
- Riker RR, et al., Dexmedetomidine vs midazolam for sedation of critically ill patients: a randomized trial. JAMA. 2009 Feb 4;301(5):489-99. doi: 10.1001/jama.2009.56. Epub 2009 Feb 2.
Quality and safety issues in the ICU
- Pronovost P, Needham D, et al. An intervention to decrease catheter-related bloodstream infections in the ICU. N Engl J Med. 2006;355:2725-32.
Respiratory Failure and Mechanical Ventilation
- Acute Respiratory Distress Syndrome Network. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. N Engl J Med. 2000 May 4;342(18):1301-8.
- Afshari A. Aerosolized prostacyclin for acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). Cochrane Database Syst Rev. 2010 Aug 4;(8):CD007733. doi: 10.1002/14651858.CD007733.pub2.
- Afshari A, et al. Inhaled nitric oxide for acute respiratory distress syndrome (ARDS) and acute lung injury in children and adults. Cochrane Database Syst Rev. 2010 Jul 7;(7):CD002787. doi: 10.1002/14651858.CD002787.pub2.
- ARDS Definition Task Force. Acute respiratory distress syndrome: the Berlin Definition. JAMA. 2012 Jun 20;307(23):2526-33. doi: 10.1001/jama.2012.5669.
- ARDS Net - Mechanical Ventilation Protocol Summary
- ARDS Net - Tidal Volume Table
- Briel M, et al. Higher vs lower positive end-expiratory pressure in patients with acute lung injury and acute respiratory distress syndrome: systematic review and meta-analysis. JAMA. 2010 Mar 3;303(9):865-73. doi: 10.1001/jama.2010.218.
- Chandra D. Outcomes of noninvasive ventilation for acute exacerbations of chronic obstructive pulmonary disease in the United States, 1998-2008. Am J Respir Crit Care Med. 2012 Jan 15;185(2):152-9. doi: 10.1164/rccm.201106-1094OC. Epub 2011 Oct 20.
- Esan A, et al. Severe hypoxemic respiratory failure: part 1--ventilatory strategies. Chest. 2010 May;137(5):1203-16. doi: 10.1378/chest.09-2415.
- Ferguson ND, et al. High-frequency oscillation in early acute respiratory distress syndrome. N Engl J Med. 2013 Feb 28;368(9):795-805. doi: 10.1056/NEJMoa1215554. Epub 2013 Jan 22.
- Guérin C, et al. Prone positioning in severe acute respiratory distress syndrome. N Engl J Med. 2013 Jun 6;368(23):2159-68. doi: 10.1056/NEJMoa1214103. Epub 2013 May 20.
- IMPROVE Study Group. A trial of intraoperative low-tidal-volume ventilation in abdominal surgery. N Engl J Med. 2013 Aug 1;369(5):428-37. doi: 10.1056/NEJMoa1301082.
- Keenan SP, et.al. Clinical practice guidelines for the use of noninvasive positive-pressure ventilation and noninvasive continuous positive airway pressure in the acute care setting. CMAJ. 2011 Feb 22;183(3):E195-214. doi: 10.1503/cmaj.100071. Epub 2011 Feb 14.
- Masip J, et al. Noninvasive ventilation in acute cardiogenic pulmonary edema: systematic review and meta-analysis. JAMA. 2005 Dec 28;294(24):3124-30.
- National Heart, Lung, and Blood Institute ARDS Clinical Trials Network. Higher versus lower positive end-expiratory pressures in patients with the acute respiratory distress syndrome. N Engl J Med. 2004 Jul 22;351(4):327-36.
- National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome (ARDS) Clinical Trials Network. Efficacy and safety of corticosteroids for persistent acute respiratory distress syndrome. N Engl J Med. 2006 Apr 20;354(16):1671-84.
- Papazian L, et al. Neuromuscular blockers in early acute respiratory distress syndrome. N Engl J Med. 2010 Sep 16;363(12):1107-16. doi: 10.1056/NEJMoa1005372.
- Papazian L, et al. Neuromuscular blockers in early acute respiratory distress syndrome. N Engl J Med. 2010 Sep 16;363(12):1107-16. doi: 10.1056/NEJMoa1005372. Supplement.
- Pipeling MR, et al. Therapies for refractory hypoxemia in acute respiratory distress syndrome. JAMA. 2010 Dec 8;304(22):2521-7. doi: 10.1001/jama.2010.1752.
- Raoof S. et al. Severe hypoxemic respiratory failure: part 2--nonventilatory strategies. Chest. 2010 Jun;137(6):1437-48. doi: 10.1378/chest.09-2416.
- Singer BD, Corbridge TC. Basic invasive mechanical ventilation. South Med J. 2009 Dec;102(12):1238-45. doi: 10.1097/SMJ.0b013e3181bfac4f.
- Singer BD, Corbridge TC. Pressure modes of invasive mechanical ventilation. South Med J. 2011 Oct;104(10):701-9. doi: 10.1097/SMJ.0b013e31822da7fa.
Sedation management
- Kress JP, Pohlman AS, et al. Daily interruption of sedative infusions in critically ill patients undergoing mechanical ventilation. N Engl J Med. 2000;342:1471-7.
- Pisani MA, Kong SYJ, et al. Days of delirium are associated with 1-year mortality in an older intensive care unit population. Am J Respir Crit Care Med. 2009; 180:1092-1097.
Sepsis, Severe Sepsis and Septic Shock
- Annane D. Corticosteroids for severe sepsis: an evidence-based guide for physicians. Ann Intensive Care. 2011 Apr 13;1(1):7. doi: 10.1186/2110-5820-1-7.
- Annane D, Bellissant E, et al. Corticosteroids for severe sepsis and septic shock: a systematic review and meta-analysis. BMJ. 2004 Aug 28;329(7464):480. Epub 2004 Aug 2.
- Annane D, Bellissant E, et al. Coritcosteroids in the treatment of severe sepsis and septic shock in adults – a systematic review. JAMA. 2009;301(22):2362-75.
- ARISE Investigators. Goal-Directed Resuscitation for Patients with Early Septic Shock. N Engl J Med. 2014 Oct 16;371(16):1496-506. doi: 10.1056/NEJMoa1404380. Epub 2014 Oct 1.
- Bernard GR, Vincent J-L, et al. Efficacy and safety of recombinant human activated protein C for severe sepsis. N Engl J Med. 2001;344:699-709.
- De Backer D, Biston P, et al. Comparison of Dopamine and Norepinephrine in the Treatment of Shock. N Engl J Med. 2010 Mar 4;362(9):779-89. doi: 10.1056/NEJMoa0907118.
- Dellinger RP, Levy MM, et al. Surviving Sepsis Campaign: International guidelines for the management of severe sepsis and septic shock: 2008. Crit Care Med. 2008; 36:296–327.
- Hollenberg SM. Vasopressor support in septic shock. Chest. 2007; 132:1678–1687.
- Kumar A, Roberts D, et al., Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock. Crit Care Med. 2006 Jun;34(6):1589-96.
- Morelli A, Ertmer C, et al. Effect of Heart Rate Control With Esmolol on Hemodynamic and Clinical Outcomes in Patients With Septic Shock A Randomized Clinical Trial. JAMA. 2013 Oct 23;310(16):1683-91. doi: 10.1001/jama.2013.278477.
- ProCESS Investigators. A Randomized Trial of Protocol-Based Care for Early Septic Shock. N Engl J Med. 2014 May 1;370(18):1683-93. doi: 10.1056/NEJMoa1401602. Epub 2014 Mar 18.
- ProCESS Investigators. Supplement to: A randomized trial of protocol-based care for early septic shock. N Engl J Med 2014;370:1683-93
- ProMISe Trial Investigators. Trial of early, goal-directed resuscitation for septic shock. N Engl J Med. 2015 Apr 2;372(14):1301-11. doi: 10.1056/NEJMoa1500896. Epub 2015 Mar 17.
- Puskarich MA, Trzeciak S, et al. Association between timing of antibiotic administration and mortality from septic shock in patients treated with a quantitative resuscitation protocol. Crit Care Med. 2011 Sep;39(9):2066-71. doi: 10.1097/CCM.0b013e31821e87ab.
- Rivers E, Nguyen B, et al. Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med. 2001;345:1368-77.
- Russell JA. Management of Sepsis. N Engl J Med. 2006;355:1699-713.
- Sprung CL1, Annane D, et al. Hydrocortisone Therapy for Patients with Septic Shock. N Engl J Med. 2008 Jan 10;358(2):111-24. doi: 10.1056/NEJMoa071366.
- Vincent JL, Sakr Y, et al. Sepsis in European intensive care units: Results of the SOAP study. Crit Care Med. 2006 Feb;34(2):344-53.
Therapeutic hypothermia for cardiac arrest
- Holzer M. Targeted temperature management for comatose survivors of cardiac arrest. N Engl J Med. 2010; 363:1256-64. [This is a NEJM clinical vignette with a thorough review of the literature and recommendations regarding use of therapeutic hypothermia following cardiac arrest]
Thromboembolic Disease
- Hao Q, Dong, BR, et al. Thrombolytic therapy for pulmonary embolism. Cochrane Database of Systematic Reviews 2015, Issue 9. Art. No.: CD004437. DOI: 10.1002/14651858.CD004437.pub4.
- Jaff MR, McMurtry MS, et al. Management of massive and submassive pulmonary embolism, iliofemoral deep vein thrombosis, and chronic thromboembolic pulmonary hypertension: a scientific statement from the American Heart Association. Circulation. 2011 Apr 26;123(16):1788-830. doi: 10.1161/CIR.0b013e318214914f. Epub 2011 Mar 21.
- Jiménez D, Aujesky D, et al. Simplification of the pulmonary embolism severity index for prognostication in patients with acute symptomatic pulmonary embolism. Arch Intern Med. 2010 Aug 9;170(15):1383-9. doi: 10.1001/archinternmed.2010.199.
- Kuo WT, Banerjee A, et al. Pulmonary Embolism Response to Fragmentation, Embolectomy, and Catheter Thrombolysis (PERFECT): Initial Results From a Prospective Multicenter Registry. Chest. 2015 Sep;148(3):667-73. doi: 10.1378/chest.15-0119.
- Piazza G, Goldhaber SZ. Acute Pulmonary Embolism: Part II: Treatment and Prophylaxis. Circulation. 2006 Jul 18;114(3):e42-7.
- Piazza G, Goldhaber SZ. Management of Submassive Pulmonary Embolism. Circulation 2010;122;1124-1129
- Young T, Tang H, et al. Vena caval filters for the prevention of pulmonary embolism. Cochrane Database Syst Rev. 2007 Oct 17;(4):CD006212.